can i use niacinamide with salicylic acid

‘An overview of ultraviolet radiation, sunscreens, and photo-induced dermatoses’, Haywood, R. (2006) Relevance of sunscreen application method, visible light and sunlight intensity to free-radical protection: A study of ex vivo human skin. Because of its ability to reduce inflammation, decongest pores and assist with exfoliation, it is commonly used to treat acne," McBride explains. Products That Combine Ceramides & Cholesterol & Fatty Acids: Centella asiatica is a tropical medicinal plant native to Southeast Asia that has antioxidant, anti-aging, and wound healing properties. That does seem like alot. Niacinamide + Salicylic Acid = Reduced Pore Size, Reduced Sebum Production. But how do we know which skincare ingredients work well together? Bonus tips: Drink lots of water. If it's all in one product and you're worried, then rest assured it doesn't really have bad horrible side effects (unless ur skin hates niacinamide and breaks out from it) Salicylic Acid - BHA Products That Combine Green Tea & Caffeine: Our skin’s hydration generally depends on two major factors; the presence of natural moisturising factors and the structure and composition of the lipids in the stratum corneum. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047947/, https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781118384824.ch10, https://www.ncbi.nlm.nih.gov/pubmed/17134422, https://doi.org/10.1111/j.1524-4725.2005.31732, https://www.ncbi.nlm.nih.gov/pubmed/952756/, https://www.ncbi.nlm.nih.gov/pubmed/24641601/, https://www.ncbi.nlm.nih.gov/pubmed/23732711, https://www.ncbi.nlm.nih.gov/pubmed/18377617, https://www.researchgate.net/publication/256618684_Free_Radicals_In_Biology_And_Medicine, https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1751-1097.1989.tb05548.x, https://www.ncbi.nlm.nih.gov/pubmed/14632206, https://www.ncbi.nlm.nih.gov/pubmed/17205635, https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1529-8019.2012.01505.x, https://www.sciencedirect.com/science/article/pii/S0022202X15358292, https://www.sciencedirect.com/science/article/pii/S0738081X09001254, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605218/#B3, https://www.ncbi.nlm.nih.gov/pubmed/18045356/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673383/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976416/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958188/, https://www.ncbi.nlm.nih.gov/pubmed/23075568, https://europepmc.org/abstract/med/21720657, https://www.jaad.org/article/S0190-9622(17)31504-9/fulltext, https://www.ncbi.nlm.nih.gov/pubmed/23951566, https://pubs.acs.org/doi/abs/10.1021/bi00382a045?journalCode=bichaw, https://core.ac.uk/download/pdf/82665629.pdf, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216025/, https://www.jaad.org/article/S0190-9622(02)00048-8/fulltext, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116297/, https://www.ncbi.nlm.nih.gov/pubmed/9731470/, https://www.researchgate.net/profile/Puziah_Hashim4/publication/260431233_The_effect_of_Centella_asiatica_vitamins_glycolic_acid_and_their_mixtures_preparations_in_stimulating_collagen_and_fibronectin_synthesis_in_cultured_human_skin_fibroblast/links/564aaf6208ae44e7a28dd030.pdf, https://www.ncbi.nlm.nih.gov/pubmed/18503551/, https://www.ncbi.nlm.nih.gov/pubmed/16311163, https://jamanetwork.com/journals/jamadermatology/article-abstract/552806, https://www.ncbi.nlm.nih.gov/pubmed/18248499, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936427/, https://www.ncbi.nlm.nih.gov/pubmed/21348540?dopt=Abstract, https://www.ncbi.nlm.nih.gov/pubmed/14756523/, https://www.sciencedirect.com/science/article/pii/S0923181104000982, https://link.springer.com/article/10.1007/s00403-016-1644-9, https://www.ncbi.nlm.nih.gov/pubmed/29663438, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699641/, https://www.spandidos-publications.com/ijmm/22/2/229, https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1473-2130.2004.00115, https://www.ncbi.nlm.nih.gov/pubmed/8543691/, https://www.tandfonline.com/doi/abs/10.3109/14764172.2012.748199, https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1524-4725.1998.tb04262.x, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840548/, https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1524-4725.1997.tb00003.x, https://www.karger.com/Article/Abstract/81498, https://www.karger.com/Article/Abstract/81500, https://www.ncbi.nlm.nih.gov/pubmed/17348991, https://www.ncbi.nlm.nih.gov/pubmed/20725554?dopt=Abstract, https://www.ncbi.nlm.nih.gov/pubmed/12100180, https://www.ncbi.nlm.nih.gov/pubmed/19845667/. ‘New insights in photoaging, UVA induced damage and skin types’. & Herman, A. Another great antioxidant pairing is green tea and caffeine. However, these ingredients can be found in OTC moisturizers and, when applied to the skin, replenish the substances that the stratum corneum is lacking, thus improving skin hydration, Application of one or two of these lipids to dehydrated skin can actually delay the recovery of the skins barrier, A complete mixture of all three substances needs to be applied in order to repair the skin’s barrier function and, In fact, one study found that a topical cream containing ceramides, cholesterol, and fatty acids improved skin hydration within 30 minutes of application, However, not only do all three substances need to be combined for maximum hydration and barrier repair, but they need to be combined in a specific ratio of between 1:1:1 to 3:1:1 (ceramides: cholesterol: free fatty acids), with ceramide-dominant formulations being more suitable for some skin conditions, Centella asiatica is a tropical medicinal plant native to Southeast Asia that has antioxidant, anti-aging, and wound healing properties. You can also not use the Niacinamide together with any Vitamin C product, because it would affect both their effectivity, but of course there’s nothing The Ordinary can do about that :). One study found that a topical combination of vitamin C and a centella asiatica extract significantly improved skin suppleness, firmness, and hydration, as well as improving the appearance of wrinkles, after 6 weeks of use, Glycolic acid, an alpha-hydroxy acid that is thought to boost collagen production, was also included in this study. Another antioxidant skincare ingredient that promotes wound-healing and boosts collagen production is vitamin C [19]. Thanks so much!! ‘Effects of Visible Light on the Skin’. If you’ve ever wondered whether you can incorporate niacinamide and acid in one skincare routine, rest assured—you definitely can! Bissett, D., Robinson, L., Raleigh, P. et al. Use salicylic acid (psoriasis or seborrheic dermatitis) as ordered by your doctor. Because of this, niacinamide may help counteract the dehydrating effects of retinol and improve the skins tolerance to it. Tfayli, A., Jamal, D., Vyumvuhore, R., Manfait, M. & Baillet-Guffroy, A. AHAs, such as glycolic and lactic acid, act as chemical exfoliants and help remove dead skin cells and loosen the top layer of skin. Photobiol. TULA Clear It Up Acne Clearing + Tone Correcting Gel: A two percent salicylic acid gel, with niacinamide halfway down the ingredients list. ‘The effect of glycolic acid on the treatment of acne in Asian skin’. Visit our online shop: https://shop.beautywithinofficial.com/ Hi guys! Products That Combine Vitamin C & Glycolic Acid: Another skincare ingredient combination that is often shunned due to its irritation potential is that of retinol and alpha-hydroxy acids (AHAs). The structure and composition of the lipids in the stratum corneum is often referred to as the lipid matrix and creates a barrier function via its mixture of ceramides, cholesterol, and free fatty acids. Farage, M., Miller, K., Elsner, P. & Maibach, H. (2013). Tanno, O., Ota, Y., Kitamura, N., Katsube, T. & Inoue, S. (2000). (2002). Haywood, R. (2006) Relevance of sunscreen application method, visible light and sunlight intensity to free-radical protection: A study of ex vivo human skin. This is because roughly 80-90% of all facial skin aging is caused by sun damage [8]. I am planning on writing a full blogpost on skin care acids, so stay tuned if you want to know more about that. ‘Exogenous lipids influence permeability barrier recovery in acetone-treated murine skin’. Vitamin C and glycolic acid are also useful for treating hyperpigmentation as both are effective at inhibiting tyrosinase and decreasing melanin production, When used together, vitamin C and glycolic acid demonstrated an ability to significantly improve hyperpigmentation, as well as reduce pore size and improve, Other research has found that glycolic acid and vitamin C combinations are particularly good at treating stretch marks by increasing epidermal and papillary dermal thickness, This further highlights an anti-aging benefit of vitamin C and glycolic acid combinations as epidermal and papillary dermal thicknesses both decrease with age leading skin to become more transparent, Another skincare ingredient combination that is often shunned due to its irritation potential is that of retinol and alpha-hydroxy acids (AHAs). Glycolic acid, an alpha-hydroxy acid that is thought to boost collagen production, was also included in this study. I was so confused. Vitamin C + Vitamin E + Ferulic Acid = Increased Effect Of Vitamin C By 8x. ‘Anti-melanogenic effects of resveratryl triglycolate, a novel hybrid compound derived by esterification of resveratrol with glycolic acid’. Glycolic Acid + Vitamin C = Increased Collagen and Skin Thickness, Reduced Hyperpigmentation. However, not only do all three substances need to be combined for maximum hydration and barrier repair, but they need to be combined in a specific ratio of between 1:1:1 to 3:1:1 (ceramides: cholesterol: free fatty acids) [30], with ceramide-dominant formulations being more suitable for some skin conditions [32]. I haven't used any product wi Theyre the miracle tools used to fight acne, wrinkles, age spots, scarring, and uneven skin tone. (2013). Acne Scars vs Acne Marks | A Guide To The Different Causes & Treatment Options. For example, glycolic acid can significantly improve the resolution of the comedones, papules, and pustules commonly experienced with acne [57]. It’s how they keep the price so low, but it also counteracts with makeup and sometimes with other products. & De Ponti, I. Salicylic acid could dry your skin and cause flakiness, tightness, and itchiness if you don’t moisturize your skin enough. Hello youthful skin! Ezra, if you have oily, acne-prone skin stop using a AHA exfoliator and switch to salicylic acid. In order to get the maximum benefits from our skincare ingredients, we should look for products that contain the above combinations. Although the natural compounds in willow bark have provided people relief from pain and fever for centuries, modern-day salicylic acid is biosynthesized, or created artificially. In one study, pre-treatment of the skin with niacinamide provided additional barrier protection and made the skin more tolerant of retinoic acid (a prescription strength version of retinol) [50]. In fact, one study found that a topical cream containing ceramides, cholesterol, and fatty acids improved skin hydration within 30 minutes of application [31]. Vitamin C is the most abundant antioxidant in the skin and is essential for the production of collagen [16]. For example, vitamin C helps to regenerate vitamin E, making it more readily available to protect the skin from free radicals. As you can imagine, the two combined may be quite irritating for skin. Resveratrol is the potent antioxidant found in grapes (and red wine!) Telang, P. (2013). The addition of, Like UV radiation, visible light can also lead to the production of free radicals. In addition, free radicals are also produced by other forms of solar radiation, including visible light and infrared radiation. Salicylic acid and retinol are medications that can help clear acne. Barbara. ‘The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer’. This can be in a toner or serum form. But with so many acids on the market, it can seem overwhelming to remember which to use and for what and which products to buy. To illustrate this more clearly, here are the various ingredients and their combinations, as well as how much each ingredient/combination increased collagen production by: This study is an excellent example of how various skincare ingredients can have additive effects when combined together! She has experience in plastic and reconstructive surgery, dermatology, and aesthetics and has received training in laser treatments. Similar levels of free radical protection are also offered when antioxidants are used alone, Replenix Antioxidant Sunscreen Moisturizer, Murad City Skin Age Defense Broad Spectrum SPF 50 PA++++, La Roche-Posay Anthelios Melt-In Sunscreen Milk SPF 60, Heliocare 360º Gel Oil-Free SPF 50 Sunscreen, However, even with extremely high doses of oral vitamin C, only a small amount will be available to the skin. What Does pH Balanced Mean? Or maybe, just maybe, will they enhance each other and let us experience the glowing skin that we have only ever dreamed of? Poli, F., Ribet, V., Lauze, C., Adhoute, H. & Morinet, P. (2005). Do not take salicylic acid (psoriasis or seborrheic dermatitis) by mouth. Green Tea + Caffeine = Increased Protection Against UVB-induced Skin Cancer. (2005). ‘Studies on the effect of salicylic acid on normal skin’. In short, salicylic acid is beta hydroxy acid (BHA) that penetrates deep into the pores and exfoliates. Products That Combine Centella Asiatica & Vitamin C: Products That Combine Centella Asiatica & Vitamin C & Glycolic Acid: As mentioned earlier, sunscreen is very very important for preventing aging and improving overall skin health. Manela-Azulay, M. & Bagatin, E. (2009). For this reason, the combination of vitamin C and centella asiatica may lead to improved anti-oxidant, collagen-boosting, and wound-healing effects. Farage, M., Miller, K., Elsner, P. & Maibach, H. (2008). ‘Pharmacological review on centella asiatica: A potential herbal cure-all’. Sincerely. Niacinamide & Retinol Together = A Perfect Pair! So will ingredient X counteract our ingredient Y? Zinc oxide is a mineral (physical/inorganic) sunscreen, which means that it protects the skin from UVA and UVB radiation by reflecting and scattering light. ‘Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color’. All their products are cruelty-free and are not sold in China. Related Reading: Niacinamide & Retinol Together = A Perfect Pair! Scientific research studies are here to help us out! They basically ‘mop-up’ the damage done by UV radiation and other environmental aging factors (smoking, pollution, etc.) When investigated separately, this combination of resveratrol and glycolic acid inhibited tyrosinase more effectively than glycolic acid alone. In fact, the anti-aging effects of vitamin C are enhanced even further when it is combined with, Timeless Skincare 20% Vitamin C, E, & Ferulic Acid Serum, SeoulCeuticals Day Glow Serum 20% Vitamin C, E, & Ferulic Acid Serum With Hyaluronic Acid. ‘Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier’. Recently, a hybrid of glycolic acid and resveratrol, resveratryl triglycolate, has demonstrated the ability to reduce sun induced pigmentation when applied twice daily for 6-8 weeks [48]. Retinol + Niacinamide = Increased Tolerability Of Retinol. This also means that salicylic acid can access sebaceous glands and reduce sebum production [6]. Iron oxide is not an approved sunscreen but is often added to mineral sunscreens to reduce white cast. Man, M., Feingold, K. & Elias, P. (1993). Kaye, E., Levin, J., Blank, I. et al. With thousands of different skincare products available, we’re often spoilt for choice. <3 A number of studies that have investigated the wound-healing benefits of centella asiatica have found that topical application of the extract increases the production of collagen [34]. ‘Vitamin C in dermatology’. Gohli, K., Patel, J. 2 Common Myths Busted! “However, like aspirin, salicylic acid also has anti-inflammatory properties which can calm the skin and minimize irritation.” Many labels for acid-based products display the percentage of acid used (i.e., 2 percent salicylic acid), informing consumers of a product’s supposed strength. Ex. Mahmoud, B., Hexsel, C., Hamzavi, I. When using hyaluronic acid and retinol, apply retinol first, then hyaluronic acid. Its effects are thought to be largely due to various saponins contained within centella asiatica extracts [33]. Considering the price, it is probably best to save this product just for the dark spots that rea Gehring, W. (2004). However, in certain formulas, the combination of glycolic acid and retinol can be well-tolerated and a complimentary and effective acne treatment. Deciem has three skin care brands: Niod, Hylamide and The Ordinary, listed in decreasing order of luxuriousness and price. But, that doesn’t mean these two can’t be part of your anti-acne routine, as well. These come up especially around my time of the month and whenever I use a wrong product (hello, over-sensitive skin!). Will they interact and leave us with irritated and painful skin? The major polyphenol present in green tea is epigallocatechin-3-gallate (EGCG) that has also been shown to have sunscreen properties [21]. It inhibits tyrosinase, the key enzyme in the production of melanin, in various ways and thus prevents the conversion of DOPA to melanin [44]. Niacinamide offers similar benefits [4], as well as reducing redness and pigmentation and improving skin barrier function [2]. that is known to reduce pigmentation and inflammation and has anti-aging properties [43]. ‘Applications of hydroxyl acids: classification, mechanisms, and photoactivity’. Because NAG and niacinamide target pigmentation in two separate ways (NAG prevents melanin production while niacinamide prevents the spread of existing melanin), they are highly likely to compliment each other when used together. The Ordinary Niacinamide 10% + Zinc 1% is a high-strength potion of vitamins and minerals. Green, B. The ordinary niacinamide worked brilliantly for me. Loden, M. (2016). ‘Vitamin E in dermatology’. In addition, glycolic acid is very good at penetrating skin [47]. N-Acetyl Glucosamine (NAG) is an amino sugar and precursor to hyaluronic acid that inhibits tyrosinase glycosylation, thus reducing melanin production [61]. For example, 2% NAG, alone, reduced the appearance of facial hyperpigmentation, but this reduction was far greater when 2% NAG was combined with 4% niacinamide [61]. Some research suggests that caffeine enhances the antioxidant effects of green tea polyphenols and that both together may help prevent free radical production and UVB-induced skin cancer [23]. For example, a combination of retinaldehyde and glycolic acid demonstrated a good tolerability and significant improvement in acne lesions after 1-3 months of use, The same combination has also demonstrated effectiveness at preventing and healing the post-inflammatory hyperpigmentation (PIH) associated with acne, Research also demonstrates that this formulation can also be used along-side benzyl peroxide and topical antibiotics without causing irritation. According to Elle magazine, dermatologist Jenny Kim says that while salicylic acid works to kill pimple-causing bacteria, retinol removes the upper layers of skin to get rid of pimples … Both have anti-aging and anti-acne effects and offer some level of UV protection. Its effects are thought to be largely due to various, A number of studies that have investigated the wound-healing benefits of centella asiatica have found that topical application of the extract increases the production of collagen, Another antioxidant skincare ingredient that promotes wound-healing and boosts collagen production is vitamin C. For this reason, the combination of vitamin C and centella asiatica may lead to improved anti-oxidant, collagen-boosting, and wound-healing effects. This means that combining the two can have an additive effect. Can you tell i love Vit C? Niacinamide is able to stabilise the skins barrier function by reducing the amount of water lost and improving hydration [51]. All content, including, but not limited to, text, images, links, and other material does not constitute medical or other professional advice, and is not intended to be a substitute for professional medical advice. Similar levels of free radical protection are also offered when antioxidants are used alone [15]. ‘Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine’. Caffeine has also demonstrated antioxidant and photoprotective effects and offers additional UV radiation and free radical protection when added to sunscreens [22]. Hydroxy acids are particularly useful for treating, For example, glycolic acid can significantly improve the resolution of the comedones, papules, and pustules commonly experienced with acne, Retinol also helps to improve acne by increasing the rate of skin cell turnover and renewal which means that dead skin cells are shed quicker. It is recommended to use a mild amino acid facial cleanser to clean the face. Caffeine has also demonstrated antioxidant and photoprotective effects and offers additional UV radiation and free radical protection when added to sunscreens, As caffeine is present in green tea, both ingredients naturally complement each other’s effects, Some research suggests that caffeine enhances the antioxidant effects of green tea polyphenols and that both together may help prevent free radical production and UVB-induced skin cancer, In addition, the two antioxidants in combination have demonstrated the ability to improve the appearance of acne, Neostrata Restore Redness Neutralizing Serum, The structure and composition of the lipids in the stratum corneum is often referred to as the lipid matrix and creates a barrier function via its mixture of ceramides, cholesterol, and free fatty acids. The Ordinary! (2005). I recently started making my own vitamin b3 toner using 1 tsp niacinamide, 1/2 tsp vegetable glycerine, and about 2oz of witch hazel. When this lipid matrix is depleted, skin can become dehydrated [25] which results in rougher and duller looking skin. by neutralizing the free radicals that are produced upon exposure to these toxins [14]. Ceramides account for about 45-50% of this mixture, cholesterol for approximately 25%, and free fatty acids for around 10-15% [25]. Yes, you can pair both of these ingredients together. With its offer of retinoids, direct acids, oils and more straightforward products, The Ordinary is known to be a very humble and no-nonsense brand. ‘Efficacy and safety of a new superficial chemical peel using alpha-hydroxy acid, vitamin C and oxygen for melasma’. ‘Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial’. ‘Nicotinamide attenuates aquaporin 3 overexpression induced by retinoic acid through inhibition of EGFR/ERK in cultured human skin keratinocytes’. You can use niacinamide in the morning and salicylic acid followed by … These two definitely address a certain skin type: the Niacinamide + Zinc is your best friend if you suffer from oily skin, and combined with the the Salicylic Acid it’s perfect to treat blemish- and acne-prone skin. Add these two ingredients when cleansing your face and they will flow away directly with the water. (2013). You can find The Ordinary in Belgium on ASOS or the British website Cult Beauty (but they’re very often sold out!). (2013). These effects are largely down to the polyphenols (antioxidant molecules) that are naturally present in green tea. N-Acetyl Glucosamine + Niacinamide = Reduced Pigmentation. Vitamin E returns the favor by increasing the action of vitamin C four-fold (4x) [19][20]. The addition of iron oxide to sunscreens also happens to broaden the UV protection of mineral sunscreen agents into the longer UVA and visible light spectrums. & Gajjar, A. Related Reading: Does Niacinamide Cause Purging? Like salacin, salicylic acid is an anti-inflammatory substance with chemical similarities to aspirin. Read all information given to you. Hello! This is particularly relevant for individuals with hyperpigmentation and melasma as visible light can increase melanin production [41]. You can use a serum or moisturizer to rebalance your skin. These two definitely address a certain skin type: the Niacinamide + Zinc is your best friend if you suffer from oily skin, and combined with the the Salicylic Acid it’s perfect to treat blemish- and acne-prone skin. Post Inflammatory Erythema: 12 Effective Treatment Options. Photochem. ‘Stratum corneum lipid phase transitions and water barrier properties’. Laura is a skincare addict and sunscreen enthusiast with more than 10 years of experience working in healthcare and over 5 years of experience working as a nurse. 5 Of The Best Hydrating Products For Acne Prone Skin. In fact, a large randomized controlled study found that the combination of niacinamide and NAG worked really well at reducing pigmentation. The combination of the two completely got rid of my under-skin bumps and any other spots, The Niacinamide helps to balance my skin’s oil-production without completely stripping it, They work really quickly, you get visible results after just one or two uses, They’re so cheap (only around 10 euros each! This makes it a perfect spot treatment while it also improves your skin’s clarity. Niacinamide and salicylic acid work together to calm and minimize breakouts, while licorice root extract and vitamin C help the niacinamide brighten hyperpigmentation and acne scars. Vitamin E is the most important lipid-soluble antioxidant in tissue and is particularly abundant in the outermost layer of the skin (the stratum corneum) where it is delivered by sebum. I’m using the salicylic acid cleanser from The Inkey List. (2011). Chamlin, S., Kao, J., Frieden, I. et al. (2016). & Brody, N. (2011). TruSkin Vitamin C … This basically means that niacinamide prevents pigment leaking into other surrounding cells. Let us know in the comments section! Here are 12 combinations of skincare ingredients that work better together! This suggests that the combination of zinc oxide and iron oxide in sunscreen is particularly beneficial for individuals with melasma. However, in certain formulas, the combination of glycolic acid and retinol can be well-tolerated and a complimentary and effective acne treatment. (2010). Al-Niaimi, F. & Chiang, N. (2017). Zinc Oxide + Iron Oxide = Increased Photoprotection, Reduced Hyperpigmentation. This skin damage occurs when free radicals produced by UV radiation alter cellular DNA and break down the collagen in the skin [9][10]. However, what was not discussed (except in the comments section) was whether or not niacinamide is similarly incompatible with other commonly used acidic compounds such as glycolic and salicylic acid. Research suggests that niacinamide can decrease the transfer of melanosomes from melanocytes to keratinocytes by up to 68% and interferes with the cell signalling pathways between keratinocytes and melanocytes [63]. Still, if both ur niacinamide and Vit C (LAA) are in 2 different products, then just separate the order and use one in AM/PM lah. When added to sunscreen, antioxidants are able to reduce the production of free radicals by up to 78%. In fact, it can actually stop the visible signs of skin aging when used correctly [7]. This website is intended for informational and/or educational purposes only. Then use The ordinary niacinamide 10% & zinc 1% for oil control you want. Thank you. But we’re already using the last skincare ingredient that they recommended and it has become our new holy grail product. Vitamin C and glycolic acid are also useful for treating hyperpigmentation as both are effective at inhibiting tyrosinase and decreasing melanin production [53][45]. Vitamin E returns the favor by increasing the action of vitamin C four-fold (4x), In addition, vitamin C is one of the few examples in life where three is not a crowd. Kameyama, K., Sakai, C., Kondoh, S. et al. Marczyk, B., Mucha, P., Budzisz, E., Rotsztein, H. (2014). Jo, D., Seok, J., Kim, S. et al. ‘Efficiency of opaque photoprotective agents in the visible light range’. Products That Combine Vitamin C & Vitamin E & Ferulic Acid: Another great antioxidant pairing is green tea and caffeine. Specifically, a mix of 0.5% ferulic acid and 1% vitamin E with 15% vitamin C increases the effects of vitamin C eight-fold (8x) [19]. In one study, pre-treatment of the skin with niacinamide provided additional barrier protection and made the skin more tolerant of retinoic acid (a prescription strength version of retinol). Can You Use Glycolic Acid and Retinol Together? I use the Niacinamide + Zinc first, all over my face (except for my nose, eyes and mouth area!) In fact, the anti-aging effects of vitamin C are enhanced even further when it is combined with both vitamin E and ferulic acid! Haywood, R., Wardman, P., Sanders, R. & Linge, C. (2003). Hughes, M., Williams, G., Baker, P., Green, A. However, NAG can be unstable when used alone [62]. Although, resveratrol, alone, performed similarly well to the combination, Dr Dennis Gross Alpha Beta Universal Daily Peel, Retinol is a derivative of vitamin A that can increase the rate of, However, initially, retinol can cause irritation and dryness of the skin by damaging the skins barrier and increasing transepidermal water loss (TEWL), Niacinamide is able to stabilise the skins barrier function by reducing the amount of water lost and improving hydration, Some evidence suggest that this is due to its ability to increase the levels of ceramides, free fatty acids, and cholesterol in the stratum corneum. ‘Human skin-depigmenting effects of resveratryl triglycolate, a hybrid compound of resveratrol and glycolic acid’. Both ingredients target both of these causes and research has found that topical combinations of salicylic acid and niacinamide can significantly reduce surface sebum levels and pore size after 12 weeks of use [2]. Specifically, 4% niacinamide combined with 2% NAG was significantly more effective at reducing pigmentation than a vehicle control formulation, Furthermore, niacinamide appears to have an additive effect when combined with NAG. Less spots, slightly mire refined pores, over all improved texture. I like how my skin looks after using for a few days! Another great skincare ingredient combination for hyperpigmentation and melasma is glycolic acid and resveratrol. Before all that, you have to know where to start. One study found that a topical combination of vitamin C and a centella asiatica extract significantly improved skin suppleness, firmness, and hydration, as well as improving the appearance of wrinkles, after 6 weeks of use [36]. ), especially in relation to the effect, The packaging is really simple and practical, no-nonsense, The formula, as I said, is not ideal. ‘Optimization of physiological lipid mixtures for barrier repair’. In fact, vitamin C is the best-known stimulator of collagen production [35]. Hydroxy acids are particularly useful for treating acne [1]. I would however not use them when my skin is dehydrated or sensitive, especially not the direct acid. Layering and mixing skincare ingredients can be overwhelming at the best of times. that is known to reduce pigmentation and inflammation and has anti-aging properties, It inhibits tyrosinase, the key enzyme in the production of melanin, in various ways and thus prevents the conversion of DOPA to melanin, Some research suggests that glycolic acid, as well as other AHAs, also inhibit tyrosinase, In addition, AHAs increase the rate of skin cell turnover which helps bring skin pigment to the surface of the skin faster where it can be shed as part of normal epidermal desquamation (skin shedding), In addition, glycolic acid is very good at penetrating skin, Recently, a hybrid of glycolic acid and resveratrol, resveratryl triglycolate, has demonstrated the ability to reduce sun induced pigmentation when applied twice daily for 6-8 weeks, When investigated separately, this combination of resveratrol and glycolic acid inhibited tyrosinase more effectively than glycolic acid alone. ‘Topical retinaldehyde with glycolic acid: study of tolerance and acceptability in association with anti-acne treatments in 1,709 patients’. & Potts, R. (1986). We have already seen earlier how vitamin C and glycolic acid enhanced each others collagen-boosting effects when combined with centella asiatica [35]. Visible light, especially high energy visible (HEV) light, represents about 39-44% of total solar radiation and enters the skin in the same way that UV radiation does [38]. Furthermore, niacinamide appears to have an additive effect when combined with NAG. Park, S., Seok, J., Kwak, J. et al. Niacinamide 10% + Zinc 1% Salicylic Acid 2% Solution Anhydrous Solutions = 2 Add number 2 to all these products if you have them. Salicylic acid can improve the signs of premature skin aging by increasing collagen levels, improving the quality of elastic fibers, and shrinking pores for a smoother complexion, as well as reducing redness and pigmentation and improving skin barrier function, As salicylic acid is oil-soluble, it easily penetrates pores in order to unclog them by loosening and detaching the skin cells and debris that build up within the hair follicle, This also means that salicylic acid can access sebaceous glands and reduce sebum production, Niacinamide reduces sebum production by decreasing the glyceride and fatty acids of surface sebum which helps to, Enlarged pores are caused by two main factors; increased sebum levels and reduced levels of collagen and elasticity in the skin. Today, I finally feel as if I have it under control thanks to lots of patience, a dietary turnover and these two products by The Ordinary: the Niacinamide 10% + Zinc 1% and the Salicylic Acid 2% Solution. Also to know i can mix Gycolic Acid with Vitamin C. Yeah! Read More. Davis, E. & Callender, V. (2010). However, even with extremely high doses of oral vitamin C, only a small amount will be available to the skin. and then the Salicylic Acid directly on spots or spotty areas. ‘Practical uses of botanicals in skin care’. Notify me of follow-up comments by email. For example, a combination of retinaldehyde and glycolic acid demonstrated a good tolerability and significant improvement in acne lesions after 1-3 months of use [58]. Just use them at different times. But are some sunscreen ingredient combinations better than others? Dreno, B., Nocera, T., Verriere, F. et al. As salicylic acid is oil-soluble, it easily penetrates pores in order to unclog them by loosening and detaching the skin cells and debris that build up within the hair follicle [5]. Ceramides account for about 45-50% of this mixture, cholesterol for approximately 25%, and free fatty acids for around 10-15%, When this lipid matrix is depleted, skin can become dehydrated. The fact that I no longer had an easy skin type was both a physical and a mental problem for me and it inspired me even more to read into skin care and get to the bottom of the problem. Stallings, A. Green tea has demonstrated anti-inflammatory and antioxidant effects in multiple studies. (2014). Other research has found that this is an additive effect. For this reason, topical application of vitamin C is required to maintain sufficient skin levels of vitamin C, Vitamin E is the most important lipid-soluble antioxidant in tissue and is particularly abundant in the outermost layer of the skin (the stratum corneum) where it is delivered by sebum. (2005). This further highlights an anti-aging benefit of vitamin C and glycolic acid combinations as epidermal and papillary dermal thicknesses both decrease with age leading skin to become more transparent [56]. http://theordinary.com/product/rdn-niacinamide-10pct-zinc-1pct-30ml?redir=1, http://theordinary.com/product/rdn-salicylic-acid-2pct-solution-30ml?redir=1. Niacinamide reduces sebum production by decreasing the glyceride and fatty acids of surface sebum which helps to reduce pore size and improve skin texture [2]. Niacinamide & Salicylic Acid Niacinamide, a water soluble form of vitamin B3, and salicylic acid, a beta-hydroxy acid, work particularly well when combined together. This multi-functional niacinamide serum is a perfect solution for those dealing with both acne and its aftermath. I always thought that Retinol and AHA could NOT be used together??? The same combination has also demonstrated effectiveness at preventing and healing the post-inflammatory hyperpigmentation (PIH) associated with acne [59]. Should I keep using them at the same time, and if so, in what order? Together, the duo keeps skin in tact and less apt to become sensitive. Use on your skin only. Berson, D., Osborne, R., Oblong, J., Hakozaki, T., Jonson, M. & Bissett, D. (2014). Therefore, it was recommended that in order to achieve optimal results from both ingredients, the two should be used separately. According to Maiman, the combination of azelaic acid, niacinamide and salicylic acid are “generally considered safe for both pregnant and lactating … Products That Combine N-Acetyl Glucosamine & Niacinamide: We have discussed 12 examples of skincare ingredient combinations where less is not more. While all patients experienced reductions in hyperpigmentation, those who used the iron oxide sunscreen experiences significantly greater improvements, Murad City Skin Age Defense Broad-Spectrum SPF 50 PA++++, Skinceuticals UV Defense Broad-Spectrum SPF50 Physical Fusion Sunscreen, Tizo 3 Tinted Face Mineral SPF40 Sunscreen, Another great skincare ingredient combination for, Resveratrol is the potent antioxidant found in grapes (and red wine!) This means you can use niacinamide and vitamin C together without any problem. Niacinamide and Hyaluronic Acid Together = Super Skin Hydration. I have long accepted that my skin will never be free from blemishes and oil-overproduction. A number of in vitro and in vivo studies have demonstrated that these lipids, particularly ceramides play a vital role in skin hydration by regulating the amount of water in and out of the skin [26][27]. The Importance Of Sunscreen: Scientific Sunscreen Guide Part I. Bissett, D., Oblong, J. It started about a year ago. Castanedo-Cazares, J., Hernandez-Blanco, D., Carlos-Ortega, B., Fuentes-Ahumada, C. & Torres-Alvarez, B. & Lupo, M. (2009). This is a great example of how a number of ingredients that when combined together, in theory, should be highly irritating to the skin. Liebel, F., Kaur, S., Ruvolo, E., Kollias, N. & Southall, M. (2012). ‘Antioxidants and the skin: Understanding formulation and efficacy’. ‘Post inflammatory hyperpigmentation: etiologic and therapeutic considerations’. While UV radiation is the most damaging form of solar radiation for the skin, it only accounts for approximately 3-7% of total solar radiation. Your email address will not be published. However, these ingredients can be found in OTC moisturizers and, when applied to the skin, replenish the substances that the stratum corneum is lacking, thus improving skin hydration [28]. That’s right, there truly are some skincare ingredient power couples! ‘Topical green tea polyphenols and caffeine as a treatment for acne vulgaris’. My other concern is can i use more of the same product in a skin care routine. ‘Sunscreen and Prevention of Skin Aging: A Randomized Trial’. Salicylic Acid + Niacinamide "Salicylic Acid is a pore-cleansing Beta Hydroxy Acid (BHA). While there are a few acid treatments out there that also give you a low dose of niacinamide (like the COSRX AHA and BHA ), I do recommend using separate products if you want to see the best results. Ingredients. Jagdeo, J. ‘Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity’. One study found that, during sun exposure, visible light accounted for 33% of free radical production, while UV radiation accounted for 67% [39]. ‘Characteristics of the aging skin’. Laura is currently working in healthcare education and writes for ScienceBecomesHer in her spare time. Iron oxide is not an approved sunscreen but is often added to mineral sunscreens to reduce white cast. In addition, vitamin C is one of the few examples in life where three is not a crowd. ‘Preliminary open-label clinical evaluation of the soothing and reepithelialisation properties of a novel topical formulation for rosacea’. In one study, individuals on a hydroquinone treatment regime were provided with a standard broad-spectrum SPF50 sunscreen or a similar sunscreen that also contained iron oxide and instructed to apply it every day. Vitamin C and vitamin E are possibly the best example of a skincare power couple as they each enhance the effects of the other. But, just like retinol, it can be drying to skin. (2008). ‘The effect of Centella asiatica, vitamins, glycolic acid and their mixtures preparations in stimulating collagen and fibronectin synthesis in cultured human skin fibroblast’. I've read several posts saying that niacinamide and salicylic acid shouldn't be used on the face at the same time, but I've also read about people who do just that and have had success with it. (2018). thanks alot, this really help me to choose and mix my skincare routine. Exfoliation or Masking (Optional) This is a completely optional step (skip to number 3 or 4 if don’t … ‘Epidermal desquamation’. Davies, M. & Marks, R. (1976). Their Azelaic acid actually formed spots - the formula/texture if it doesn’t shut my skin. While UV radiation is the most damaging form of solar radiation for the skin, it only accounts for approximately 3-7% of total solar radiation. Both have anti-aging and anti-acne effects and offer some level of UV protection [1][2]. 82, 1123– 1131. Wang, C., Huang, C., Hu, C. & Chan, H. (1997). (2008). Follow all instructions closely. ‘Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin’. Hashim, P. (2014). Same as AM but without SPF Niacinamide can help decrease retinol irritation, and on top of that, the added barrier function benefit definitely is a plus! Sunscreen + Antioxidants = Increased Photoprotection. If your makes your skin itchy, don’t use it all.

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